December, 1992 — FDA approves paroxetine (Paxil) for major depressive disorder (MDD) in adults in December, 1992 on the basis of the June 19, 1991 Review. When Study 329 becomes controversial, many critics acknowledge that while the adolescent studies appear to show that the drug does not work and might not be safe for this population, it has been proven safe and effective for adults when the actual data did not support this conclusion. A proposal for use of the drug for adolescents is initiated.