April, 1994 — Study 329 trials begin
Sept 28, 1994 — Trial: Joyce Fentress et al vs Eli Lilly commences in Louisville, Kentucky. Joseph Wesbecker was depressed, and his physician puts him on Prozac a second time in August, 1989, although he has a history of bad reaction to the drug. After two weeks in which his behaviour is increasingly bizarre and erratic, he goes to the print shop where he works, armed with an AK47, and wounds 12 people, kills 8 (including Kenneth Fentress), then turns the gun on himself. The evidence against the drug is solid so the defence uses a strategy of discrediting Wesbecker.
Oct 24, 1994 — Testimony: An expert witness on the proper conduct of randomized control trials (RCT) to test medication for approval, Dr Nancy Lord, testifies in Fentress about the trials conducted in the 1980's to support Lilly's FDA application to approve Prozac. She notes that "The data was flawed for a number of reasons"(See transcript pages 47 - 50):
Back in 1984 Eli Lilly is manipulating data to prove efficacy and safety that is not real. Because they are first out of the gate, the Prozac data escapes the same scrutiny to which subsequently introduced SSRIs are subjected.
1994 — Italy's Giovanna Fava, editor-in-chief of the journal Psychotherapy and Psychosomatics, writes that "long-term use of antidepressant drugs may increase, in some cases, the biochemical vulnerability to depression, and worsen its long-term outcomes and symptomatic expression. Since then, Fava has periodically revisited this issue, and he recently published an updated review of the literature in Progress in Neuro-Psychopharmacology and Biological Psychiatry.""Here is a sampling of what he found in the research literature: