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Study 329

Medicine’s Most Infamous Clinical Trial

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Peer Reviews Keller et al.

The Healthy Skepticism website has many documents relating to the original Paxil Study 329: Paroxetine vs Imipramine vs Placebo in Adolescents.

Here are the links to the drafts and peer reviews:

  1. Draft I. 18 Dec 1998.
  2. Draft ?II with ?Keller’s annotations. 11 Feb 1999.
  3. Draft III. 22 Mar 1999.
  4. Draft submitted to JAMA. 30 July 1999.
  5. JAMA Reviews. 22 Oct 1999.
  6. Response to JAMA reviews. 10 Dec 1999.
  7. Draft VI, submitted to JAACAP. 25 Apr 2000.
  8. JAACAP Reviews.
  9. Response to JAACAP reviewers.
  10. Response to Dulcan.
  11. Comparison of first to final draft
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